The researchers reviewed existing data on the mechanisms underlying vitamin D’s effects on fatigue, the results of their work are published in Nutrients,
They found that vitamin D intervenes in human physiological processes, potentially influencing the pathophysiology of many fatigue-related conditions, including neurodegenerative, cardiovascular, rheumatic, diabetic, reproductive, and cancer disorders.
Vitamin D: How Does It Control Fatigue?
Some studies show that vitamin D controls fatigue by regulating inflammation and neurotransmitters. It also influences biochemical responses such as oxidative stress factors and inflammatory cytokines that are involved in the pathophysiology of fatigue. By regulating these processes, vitamin D can help alleviate fatigue.
Mechanisms of vitamin D in reducing oxidative stress
This vitamin participates in several processes including redox reactions, formation of reactive oxygen species (ROS) and mitochondrial function. These mechanisms play a key role in reducing oxidative stress, a major cause of fatigue. Vitamin D supplementation may improve skeletal muscle mitochondrial functions by reducing oxidative stress. In addition, vitamin D regulates the development of klotho, a protein with anti-aging effects, which increases tolerance to oxidative stress and prevents excessive production of ROS.
Immunological and inflammatory effects of vitamin D
It also regulates immune functions and inflammatory processes. Studies have shown a cause-and-effect relationship between inflammation and vitamin D, which promotes the anti-inflammatory actions of cytokines. This mechanism may be particularly important in the treatment of autoimmune diseases associated with fatigue.
Monitoring of vitamin D levels is recommended in patients with fatigue symptoms, particularly in the elderly and in patients with multiple sclerosis, where strong links between vitamin D and fatigue have been established. However, more research is needed to better understand its effect on fatigue in specific conditions such as fibromyalgia, rheumatological disorders, myasthenia gravis, and cancer.
Before taking any vitamin D supplement, it is advisable to talk to your doctor, especially to avoid any risk of overdose which can prove toxic to the body.
