A healthy lifestyle and especially a good diet can help slow brain aging. So what is the mechanism that explains the link between the two?
What if the only way to live longer is to eat less? This is the conclusion of a study conducted by researchers at the Buck Institute for Research on Aging. They found that limiting the amount of food a person eats also helps protect the brain from aging. Their study, recently published in the journal NatureIn fact, a specific gene has been identified that is strengthened by calorie restriction and that contributes to healthy aging of the brain.
The brain, in particular, is affected by aging
The team decided to study the effect of calorie restriction on brain aging because dietary restriction is an important intervention in the aging process and the brain is a particularly vulnerable organ during aging. “Many people practice various forms of calorie restriction, esp Intermittent fasting. This is the first step in understanding the impact of these efforts on brain aging.”Buck Institute for Research on Aging professor and study co-author Dr. Underlines Lisa Ellerby.
For this study, Dr. Ellerby and his team used fly models and human cells to investigate how calorie restriction might affect brain aging. Flies were reared either on a normal diet or fed only 10% of their normal diet.
“Prevent or slow the progression of neurodegenerative diseases”
The study allowed the researchers to identify five genes whose specific variants had a significant effect on longevity under dietary restriction. One of them is the mtd gene in flies, which corresponds to the oxidative resistance 1 (OXR1) gene, known for its neuroprotective role in humans.
“Age is the single greatest risk factor for developing brain diseases. Postponing or slowing the pace of aging can delay many age-related diseases and therefore neurological diseases. Regarding brain diseases,Alzheimer’s And no Parkinson’s, there is no treatment to cure them. It is therefore important that we understand how to prevent or slow the progression of neurodegenerative diseases.”, Dr. Allerby believes. She and her colleagues believe these findings could be used in the future to help identify potential therapeutic targets to slow aging and age-related neurodegenerative diseases.
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