Proteins under the influence of other proteins
According to the results of a study published this Wednesday, January 31, in the journal Cell Discovery, scientists have demonstrated the key role of a protein, the SMDY2 protein, in the appearance of metastasis. In aggressive breast cancer, this protein hijacks the role of another protein, BCAR3. This is responsible for the migration ability of cells. But it is also under the influence of SMDY2, which is abundantly present in aggressive breast cancers. “In vitro experiments show that the presence or at least stimulation of SMYD2 is required for the growth of metastatic cancer cells and their ability to migrate and invade their environment,” the CNRS press release clarifies.
Time to win
The scientists then inhibited the protein in question in mice suffering from early-stage breast cancer without metastases. “A comparative analysis of the evolution of cancer growth stages between treated and untreated mice finally highlighted the relationship between the inhibition of SMYD2, blocking its action on BCAR3, and the complete absence of metastasis”.
This discovery may allow the development of treatments that will prevent the rapid occurrence of metastasis. Objective: To save time and identify appropriate treatment for this aggressive cancer.
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