While not applicable to humans
A few days ago we were talking about a professor of molecular biogerontology at University Institute of Inflammation and Aging from Birmingham, in that Great Britain, Joao Pedro de Magalhães, who is holding it “If research on new gene therapy methods fully uncovers the mechanisms of aging, we will not only extend life by decades, as is currently assumed, but we can reach an age of 1,000 to 20,000 years.”although in order for humans to reach those years, the cells must be reprogrammed. Today we are talking about a drug associated with aging.
A new discovery in this sense, which refers to one of the nine causes responsible for aging: cellular aging. It is a mechanism that stops damaged cells from dividing and destroys them so they cannot reproduce. The mechanism, which, as explained in top, “It contributes, for example, to stopping cancer and helps to model tissues in the embryonic stage of development.”
From the same background, they point out that although this is a very useful biological mechanism, as we age, it also contributes to the development of diseases. “The reason seems to be that the immune system is no longer able to effectively destroy these old cells that accumulate in the tissues, which impairs its work,” explain.
A drug that cannot yet be used on humans
Recently, a group of Spanish scientists from Open University of Catalonia (UOC) And University of Leicester (UK)), have developed a new method to slow down the aging process by removing old cells from tissues. The results of this work are published in Scientific Reports.
it’s an antibody “is able to recognize specific proteins on the surface of these old cells, cling to them and apply a drug that kills them without affecting the rest of healthy cells, thereby minimizing potential side effects.”“, they explain from the same environment.
Something that could help develop effective therapies to slow the progression of aging-related diseases and, over time, help slow the aging process and improve life expectancy and quality of life in older people.
Physician and researcher UOC, Salvador Masipwho is at the forefront of research, explained that they are based on treatments already used in cancer and target certain proteins that are “present on the surface of cancer cells” and transfer them to senescent cells.
Previous experiments have already been carried out in the laboratory on animal models, which have shown that if these cells are eliminated with drugs, the progression of the disease and age-related degeneration can be slowed down. This has been achieved with a new class of drugs called senolytics, which are not very specific and have side effects that make them difficult to use in humans. And it is a very specific and remotely controlled second-generation senolytic drug that this group of researchers has developed.
To do this, they used an antibody, which they taught to recognize and attach to aging cells, just like the antibodies in our body recognize germs and protect us from them. “We designed these antibodies to be able to recognize old cells, and we applied a toxic charge to them so that they would destroy them as if they were guided missiles.”, the researcher says.